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Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
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Published on: February 5, 2018

Reference materials for new psychoactive substances.

Roland P Archer1, Ric Treble, Keith Williams

  • 1States Analyst's Laboratory, Longue Rue, St Martin's, Guernsey GY4 6LD.

Drug Testing and Analysis
|July 12, 2011
PubMed
Summary
This summary is machine-generated.

The rapid emergence of novel psychoactive substances necessitates faster production of certified reference materials for accurate identification and quantification. New strategies and collaboration are essential for reference material suppliers to meet evolving laboratory needs.

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Area of Science:

  • Forensic Chemistry
  • Analytical Chemistry
  • Pharmacology

Background:

  • Historically, new psychoactive substances (NPS) emerged slowly, but over 101 have been reported since 2006.
  • The increasing prevalence of NPS necessitates the development of certified reference materials for reliable identification and quantification.

Purpose of the Study:

  • To address the challenges in producing certified reference materials for newly emerging psychoactive substances.
  • To explore new strategies for reference material production and certification in response to the rapid market entry of NPS.

Main Methods:

  • Discussion of synthesis challenges for NPS, using cathinones as a case study.
  • Exploration of alternative sourcing for reference materials, including pharmaceutical impurities and internet-sourced products.
  • Analysis of commercial difficulties posed by the transient market presence of NPS.

Main Results:

  • Traditional reference material production methods are insufficient for the current pace of NPS emergence.
  • Synthesis of NPS for reference materials presents significant challenges, including complexity and the use of controlled substances.
  • Alternative sources can be utilized but require careful conversion and certification.

Conclusions:

  • Reference material suppliers must adopt innovative strategies to meet the demand for NPS standards.
  • Collaboration among stakeholders is crucial for rapid identification of new reference material requirements.
  • Financial support, potentially through national or international commissioning, may be needed to sustain reference material development.