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Physiological cyclic AMP stimulation and oncogene mRNA levels in HL-60 cells
U Moens1, B E Bang, J Aarbakke
1Virological Research Group, University of Tromsø, Norway.
Life Sciences
|January 1, 1990
Abstract:
Altered gene expression of the proto-oncogenes c-fos and c-myc is associated with differentiation of the human promyelocytic leukemia (HL-60) cells. We studied changes of cyclic AMP levels and c-fos and c-myc mRNA levels after stimulation with theophylline and theophylline plus isoproterenol. Reduced c-fos and c-myc mRNA levels were detected, but the reduction could not, however, be related to the observed alternations in cyclic AMP concentrations. Expression of c-jun and c-Ha-ras was not affected under these conditions.