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Updated: May 31, 2026
07:31
Nitropeptide Profiling and Identification Illustrated by Angiotensin II
Published on: June 16, 2019
S-Nitrosylation signaling regulates cellular protein interactions.
Nadzeya V Marozkina1, Benjamin Gaston
1University of Virginia School of Medicine, Division of Pediatric Respiratory Medicine, PO Box 800386, Charlottesville, VA 22908, USA. nvm6v@virginia.edu
Biochimica Et Biophysica Acta
|July 13, 2011
Summary
S-Nitrosothiols, generated by specific enzymes, mediate localized cell signaling. These S-nitrosothiol reactions are tightly regulated, impacting fundamental cellular processes.
Area of Science:
- Biochemistry
- Cell Biology
- Molecular Signaling
Background:
- S-Nitrosothiols are synthesized by nitric oxide synthases and metalloproteins.
- Unlike nitric oxide, S-nitrosothiols engage in localized, covalent signaling within specific cellular compartments.
- These signaling events are under enzymatic control.
Purpose of the Study:
- To highlight the role of S-nitrosothiols in cellular regulation.
- To discuss the enzymatic control of S-nitrosothiol reactions.
- To emphasize the significance of S-nitrosylation in cell biology.
Main Methods:
- Review of literature on S-nitrosylation.
- Analysis of enzymatic regulation in cellular signaling.
- Discussion of S-nitrosylation's impact on cell biology.
Main Results:
- S-Nitrosylation is identified as a regulated signaling reaction.
- S-Nitrosothiols participate in localized and compartmentalized signaling.
- Enzymatic regulation governs S-nitrosothiol-mediated reactions.
Conclusions:
- S-Nitrosylation is a critical regulated signaling mechanism in cells.
- The localized and enzymatic nature of S-nitrosothiol reactions is key to their function.
- Understanding S-nitrosylation is vital for comprehending normal cell biology.
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