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Related Experiment Video

Updated: May 31, 2026

In vivo Optogenetic Stimulation of the Rodent Central Nervous System
09:37

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

Published on: January 15, 2015

Optogenetics in neural systems.

Ofer Yizhar1, Lief E Fenno, Thomas J Davidson

  • 1Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Neuron
|July 13, 2011
PubMed
Summary
This summary is machine-generated.

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Optogenetics, a neuroscience tool, uses single-component proteins for targeted brain perturbation. This technology advances understanding of brain function and dysfunction by overcoming limitations of older methods.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biotechnology

Background:

  • Understanding brain function requires both observational and perturbational technologies.
  • Perturbational techniques have not kept pace with observational methods in neuroscience.
  • Optogenetics offers a solution to bridge this technological gap.

Purpose of the Study:

  • To provide a primer on optogenetics applications in neuroscience.
  • To focus on single-component optogenetic tools.
  • To highlight challenges and considerations for using these tools.

Main Methods:

  • Utilizing optogenetics, a technique that uses light to control genetically modified cells.
  • Focusing on single-component tools that combine light sensitivity and effector function in one protein.

More Related Videos

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
13:44

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

Published on: September 2, 2013

Related Experiment Videos

Last Updated: May 31, 2026

In vivo Optogenetic Stimulation of the Rodent Central Nervous System
09:37

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

Published on: January 15, 2015

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
13:44

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

Published on: September 2, 2013

  • Discussing experimental design and technical considerations for neuroscience research.

    • Main Results:

    • Single-component optogenetic tools enable new classes of investigation in neural systems.
    • These tools offer reliability and targetability for precise neural manipulation.
    • Optogenetics enhances the ability to perturb neural circuits with high specificity.

    Conclusions:

    • Optogenetics, particularly single-component tools, is crucial for advancing neuroscience research.
    • These tools address the need for faster and more specific neural perturbation methods.
    • Further development and careful application of optogenetics will deepen our understanding of the brain.