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Sectioning Mammary Gland Whole Mounts for Lesion Identification
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A practical approach to grossing breast specimens.

Lei Huo1

  • 1Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. leihuo@mdanderson.org.

Annals of Diagnostic Pathology
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Pathology grossing guidelines for breast specimens have evolved with modern diagnostics. This article provides practical recommendations for grossing breast excisions and sentinel lymph nodes based on current practices.

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Area of Science:

  • Pathology
  • Surgical Pathology
  • Oncology

Background:

  • Core-needle biopsy has largely replaced surgical biopsy for initial breast lesion assessment.
  • Definitive diagnoses are now common before surgical excision.
  • Breast-conserving therapy and neoadjuvant therapy are widely adopted treatment modalities.

Purpose of the Study:

  • To provide practical guidelines for the gross examination of breast excision specimens.
  • To offer recommendations for grossing sentinel lymph nodes.
  • To reflect current practices in breast cancer pathology specimen handling.

Main Methods:

  • Review of institutional experience and current practices in breast specimen grossing.
  • Integration of diagnostic advancements like image-guided core-needle biopsy.
  • Standardization of procedures for excision specimens and sentinel lymph nodes.

Main Results:

  • Established guidelines for grossing breast excision specimens.
  • Provided specific protocols for the examination of sentinel lymph nodes.
  • Addressed the evolving landscape of breast pathology specimen handling.

Conclusions:

  • Grossing procedures for breast specimens require adaptation to contemporary diagnostic and therapeutic approaches.
  • Standardized guidelines are essential for accurate pathological assessment of breast lesions and lymph nodes.
  • This article offers a practical framework for pathologists managing breast specimens.