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Updated: May 31, 2026

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Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
Published on: August 10, 2017
Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors
Yu Luo1, Hao-Min Liu, Ming-Bo Su
1Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China.
Bioorganic & Medicinal Chemistry Letters
|July 13, 2011
Abstract:
Two natural piperamides (piperlonguminine and refrofractamide A) and their derivatives were synthesized and evaluated for inhibitory activity against histone deacetylases, as well as the HCT-116 human colon cancer cell line. The preliminary structure activity relationship was discussed. Compounds featuring a hydroxamic acid moiety exhibited moderate HDAC activity and in vitro cytotoxicity.

