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[Hypertension as predictive factor in renal cell cancer treated with antiangiogenic therapy]

Luciana Gennari1, Javier Belinsky, Claudio Graziano

  • 1Unidad Oncología, Hospital General de Agudos Carlos G. Durand, Buenos Aires, Argentina.

Medicina
|July 13, 2011
PubMed

Insights

High blood pressure in patients receiving antiangiogenic therapy for advanced kidney cancer may predict a better treatment response. This finding suggests hypertension could serve as a valuable clinical predictor for these therapies.

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Context:

  • Recent advancements in understanding oncogenesis have yielded novel therapies for advanced kidney cancer.
  • Targeted therapies include antiangiogenics (vascular endothelium-derived factor inhibitors) and mTOR inhibitors.

Purpose:

  • To identify molecular and clinical predictors for antiangiogenic therapy in advanced kidney cancer.
  • To correlate specific toxicities, such as hypertension, with treatment efficacy.

Summary:

  • Antiangiogenic agents, used in advanced kidney cancer treatment, have a distinct toxicity profile including hypertension.
  • A retrospective analysis indicated that patients who developed hypertension while on antiangiogenic therapy exhibited higher response rates and improved disease-free intervals.
  • Hypertension emerged as a potential clinical predictor of treatment success.

Impact:

  • Identifying predictors like hypertension can optimize patient selection for antiangiogenic therapies.
  • This may enhance treatment efficacy and mitigate unnecessary toxic exposure in non-responsive patients.
  • Further validation in larger cohorts is recommended to confirm hypertension as a reliable clinical predictor.

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