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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 31, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Structure-function relationship in glaucoma using spectral-domain optical coherence tomography.

Harsha L Rao1, Linda M Zangwill, Robert N Weinreb

  • 1Hamilton Glaucoma Center, University of California at San Diego, La Jolla, CA 92093-0946, USA.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 13, 2011
PubMed
Summary
This summary is machine-generated.

Spectral-domain optical coherence tomography (SDOCT) reveals strong structure-function relationships in glaucoma, particularly with retinal nerve fiber layer and macular inner retinal thickness measurements. A linear model effectively evaluates these glaucoma associations.

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Last Updated: May 31, 2026

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma is a progressive optic neuropathy characterized by vision loss.
  • Understanding the structure-function relationship is crucial for glaucoma diagnosis and management.
  • Spectral-domain optical coherence tomography (SDOCT) provides detailed structural measurements of the optic nerve and retina.

Purpose of the Study:

  • To determine the structure-function relationship in glaucoma using SDOCT-derived structural measurements.
  • To evaluate this relationship using a linear model.

Main Methods:

  • A cross-sectional study analyzed data from the Diagnostic Innovations in Glaucoma Study (DIGS) and African Descent and Glaucoma Evaluation Study (ADAGES).
  • Structure-function relationships were assessed using standard automated perimetry (SAP) and SDOCT within a 6-month interval.
  • The strength of the relationship was quantified by the coefficient of determination (R(2)) and evaluated with a linear model.

Main Results:

  • Analysis included 579 SAP and SDOCT examinations from control subjects, patients with suspected glaucoma, and patients with glaucoma.
  • The R(2) for the association between SAP total deviation and SDOCT variables ranged from 0.01 for the nasal rim area to 0.30 for inferior inner retinal thickness at the macula.
  • The linear model demonstrated a good fit for the data.

Conclusions:

  • The strongest structure-function associations were observed between SDOCT retinal nerve fiber layer measurements at arcuate areas and inner retinal thickness at the macula.
  • The linear model is a valuable tool for studying the structure-function relationship in glaucoma.