Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Neuronal Communication01:28

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application Timing-Dependent Impact of Donor Source on Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation for Adult T-Cell Leukemia/Lymphoma.

Hematological oncology·2026
Same author

Absence of Pretransplant Peripheral Blasts Is a Favorable Factor in Allogeneic Stem Cell Transplantation for Advanced Acute Lymphoblastic Leukemia.

Transplantation and cellular therapy·2026
Same author

Improvements over time in survival after post-transplant relapse of adult T-cell leukaemia/lymphoma and trends of salvage therapy in a real-world experience.

British journal of haematology·2026
Same author

Gilteritinib response in acute myeloid leukemia harboring a rare FLT3 juxtamembrane domain mutation with subsequent clonal evolution.

Annals of hematology·2026
Same author

Impact of CD34<sup>+</sup> cell dose on outcomes of related allogeneic PBSCT in adult AML patients.

British journal of haematology·2026
Same author

HLA-matched versus haploidentical donor transplantation with post-transplant cyclophosphamide: a study on behalf of the donor/source working group of the Japanese society for transplantation and cellular therapy.

Annals of hematology·2026

Related Experiment Video

Updated: May 31, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

[Calcium channels regulate neuronal function, gene expression, and development].

Akito Nakao1, Yoshinori Takada, Yasuo Mori

  • 1Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto, Japan.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|July 13, 2011
PubMed
Summary

Calcium ions (Ca2+) are vital secondary messengers. This review explores how voltage-dependent calcium channels (VDCCs) and transient receptor potential (TRP) channels regulate neuronal functions.

More Related Videos

Subcellular Imaging of Neuronal Calcium Handling In Vivo
07:14

Subcellular Imaging of Neuronal Calcium Handling In Vivo

Published on: March 17, 2023

Functional Calcium Imaging in Developing Cortical Networks
16:33

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

Related Experiment Videos

Last Updated: May 31, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

Subcellular Imaging of Neuronal Calcium Handling In Vivo
07:14

Subcellular Imaging of Neuronal Calcium Handling In Vivo

Published on: March 17, 2023

Functional Calcium Imaging in Developing Cortical Networks
16:33

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Biochemistry

Context:

  • Intracellular calcium ions (Ca2+) act as critical secondary messengers.
  • Elevated intracellular Ca2+ levels occur via external influx or endoplasmic reticulum release.
  • Plasma membrane Ca2+ influx involves voltage-dependent calcium channels (VDCCs), ligand-gated channels, and transient receptor potential (TRP) channels.

Purpose:

  • To review the mechanisms of Ca2+ signaling through VDCCs and TRP channels.
  • To elucidate the roles of these channels in mediating neuronal processes.

Summary:

  • VDCCs are activated by membrane depolarization, mediating essential functions like neurotransmitter release and gene transcription.
  • TRP channels, a diverse family of cation channels, function as cellular sensors activated by various stimuli, crucial for neuronal growth, development, survival, and death.
  • Both VDCCs and TRP channels are key players in Ca2+ signaling within the nervous system.

Impact:

  • Provides a comprehensive overview of Ca2+ signaling pathways mediated by VDCCs and TRP channels.
  • Highlights the significance of these channels in fundamental neuronal processes.
  • Offers insights into the molecular mechanisms underlying neuronal function and dysfunction.