Determinants and dynamics of genome accessibility

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Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq
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Oliver Bell1, Vijay K Tiwari, Nicolas H Thomä

  • 1Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA. olibell@stanford.edu

Nature Reviews. Genetics
|July 13, 2011
PubMed

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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