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Related Experiment Video

Updated: May 31, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Primary renal synovial sarcoma.

Vandana U Grampurohit¹, Aneel Myageri, Ravikala V Rao

¹Department of Pathology, S.D.M. College of Medical Sciences and Hospital, Dharwad, India.

|July 13, 2011

Summary

This summary is machine-generated.

Primary synovial sarcoma (SS) of the kidney is a rare cancer. This case highlights diagnostic challenges and the importance of molecular testing for poorly differentiated SS, aiding accurate diagnosis and treatment.

Keywords:

Kidney poorly differentiated synovial sarcoma

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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Murine Bilateral Renal Lymphadenectomy

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Published on: December 30, 2025

Area of Science:

Oncology
Pathology
Genetics

Background:

Primary synovial sarcoma (SS) of the kidney is an exceptionally rare renal tumor.
Accurate diagnosis can be challenging due to its rarity and potential misdiagnosis as renal cell carcinoma.

Observation:

A 21-year-old female presented with a kidney tumor initially suspected as renal cell carcinoma.
The tumor exhibited cystic and solid areas with hemorrhage, and histologically showed poorly differentiated cells with a hemangiopericytoma-like vascular pattern.

Findings:

Morphological and immunohistochemical analyses confirmed the diagnosis of poorly differentiated SS of the kidney.
This case represents the eighth documented instance of the poorly differentiated variant, adding to the ~34 reported cases globally.
The hemangiopericytoma-like histology is a common feature in poorly differentiated renal SS.

Implications:

Early and accurate diagnosis of renal SS is crucial for appropriate patient management.
Molecular confirmation using reverse transcriptase-polymerase chain reaction to detect the SYT-SSX fusion gene is vital for definitive diagnosis.
Further research into rare renal tumors like SS is necessary to improve understanding and treatment strategies.