Recombinant cytokines from plants.

Area of Science:

• Biotechnology
• Molecular Biology
• Plant Science

Background:

• Plant-based platforms have been utilized for pharmaceutical protein production for two decades.
• Despite advancements, the number of commercialized plant-made pharmaceuticals remains limited.
• Cytokines, crucial for treating cancer and immune disorders, face high production costs, making them ideal candidates for plant-based biomanufacturing.

Purpose of the Study:

• To review recent advancements in the cost-effective production of animal cytokines using plant-based systems.
• To explore the potential of plant molecular farming for therapeutic protein generation.

Main Methods:

• Review of existing literature on plant-made pharmaceuticals and cytokine production.
• Analysis of research exploring plant systems for biomanufacturing animal cytokines.

Main Results:

• Several research groups have investigated the feasibility of producing animal cytokines in plants.
• Plant-based systems show promise for reducing the high production costs associated with traditional cytokine manufacturing.

Conclusions:

• Plant-based biomanufacturing presents a viable strategy for the cost-effective production of therapeutic cytokines.
• Further research and development are needed to overcome challenges and increase the commercialization of plant-made pharmaceuticals.