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Management of hypertension in high-risk ethnic minority with heart failure

M Demede1, A Pandey, L Innasimuthu

  • 1Division of Cardiovascular Medicine, Department of Medicine SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USA.

International Journal of Hypertension
|July 13, 2011
PubMed

Insights

African-American adults face higher hypertension and heart failure rates, often resisting treatment. This review highlights disparities and the need for targeted research and therapies for this population.

Area of Science:

  • Cardiology
  • Public Health
  • Genetics

Background:

  • Hypertension (HTN) and heart failure (HF) are leading global causes of mortality and morbidity.
  • Current research predominantly features white populations, limiting understanding of HTN/HF in diverse groups.
  • African-American adults exhibit the highest global HTN rates (44%) and treatment resistance.

Purpose of the Study:

  • To examine the pathophysiology and treatment of hypertension in African-American patients with heart failure.
  • To underscore the significance of racial disparities in HTN and HF.
  • To identify gaps in clinical trial representation and advocate for targeted research.

Main Methods:

  • Literature review focusing on pathophysiology, secondary hypertension causes, and treatment strategies.
  • Analysis of existing clinical trial data, noting underrepresentation of African Americans.
  • Inclusion of emerging research on obstructive sleep apnea (OSA) in HTN/HF management.

Main Results:

  • Significant racial disparities exist in HTN and HF pathophysiology and treatment response.
  • African Americans have historically been underrepresented in clinical trials until trials like A-HEFT.
  • Obstructive sleep apnea treatment shows promise in managing HTN and HF.

Conclusions:

  • There is a critical need for more randomized clinical trials focused on African-American patients.
  • Innovative treatment options tailored to the specific needs of this demographic are required.
  • Addressing racial disparities is essential for improving HTN and HF outcomes in African Americans.

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