Related Experiment Video
Updated: May 31, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
Fulminant varicella zoster infection with multiorgan involvement: a case report
Sudheer P S Ahamed1, Abdullah Balkhair, Rajan Krishnan
1Department of Medicine, Armidale Rural Referral Hospital, Armidale, New South, Wales, Australia;
Insights
Varicella zoster infections, typically mild in children, can be severe and life-threatening in adults. This case report details a young, immunocompetent female experiencing fulminant varicella with multiorgan involvement.
Area of Science:
- Infectious Diseases
- Virology
- Immunology
Background:
- Varicella zoster virus (VZV) infections are common, usually mild in children.
- Severe VZV infections can occur in adults and immunocompromised individuals.
- Fulminant varicella is rare in immunocompetent young adults.
Purpose of the Study:
- To report a rare case of fulminant varicella infection.
- To highlight the potential for severe VZV disease in immunocompetent young adults.
- To emphasize the importance of considering VZV in severe systemic illness.
Main Methods:
- Case report presentation.
- Clinical case review.
- Literature review for comparison.
Main Results:
- A young, immunocompetent female presented with severe, disseminated varicella zoster infection.
- The patient experienced multiorgan involvement.
- The clinical course was unexpectedly severe for an immunocompetent individual.
Conclusions:
- Varicella zoster virus can cause severe, fulminant disease even in immunocompetent young adults.
- Multiorgan involvement signifies a critical illness.
- Prompt recognition and management are crucial for severe VZV cases.
Abstract:
Varicella zoster infections are considered to be mild and ubiquitous infections predominantly affecting the paediatric population. However, in adults and in specific groups of patients, such as those who are immunosuppressed, varicella infections can be fulminant and life threatening. We here present a case report of a young female patient with a normal immune system who had a fulminant varicella infection with multiorgan involvement.
Related Concept Videos
Chickenpox
Hypersensitivity Reactions: Immune-Complex Reactions
Cytomegalovirus Disease
Encephalitis ll: Pathophysiology
Rocky Mountain Spotted Fever
Pneumonia III: Complications and Assessment