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Perioperative mechanical circulatory support in children with critical heart disease
1Divisions of Critical Care Medicine and Cardiology, St. Louis Children's Hospital, Washington University School of Medicine, One Children's Place, NWT 8th Floor, St. Louis, MO, 63110, USA, pchecchia@wustl.edu.
Insights
Mechanical circulatory support devices offer a vital "bridge" for patients with cardiovascular failure, improving survival in critical situations like cardiac arrest. Optimal timing and patient selection are key to maximizing the benefits of these life-saving interventions.
Area of Science:
- Cardiology
- Critical Care Medicine
- Biomedical Engineering
Background:
- Mechanical circulatory support (MCS) is a recognized treatment for perioperative cardiovascular failure.
- MCS devices function as a "bridge" to survival, recovery, or further decision-making.
- Indications include myocarditis, acute myocardial insult, post-surgical low cardiac output, and congenital heart disease.
Purpose of the Study:
- To discuss the role and application of mechanical circulatory support in managing cardiovascular failure.
- To highlight the "bridge" concept in various clinical scenarios, including cardiac arrest.
- To emphasize the importance of appropriate patient selection and monitoring for effective MCS deployment.
Main Methods:
- Review of the established use of mechanical circulatory support devices.
- Discussion of clinical scenarios where MCS is applied, such as cardiac arrest and perioperative decompensation.
- Emphasis on risk minimization strategies (bleeding, infection, thrombosis) for safe MCS utilization.
Main Results:
- MCS can salvage patients with otherwise certain mortality, particularly during cardiac arrest.
- The effectiveness of MCS is most pronounced in patients not at the extremes of the survival curve.
- Risk management strategies can minimize complications associated with MCS.
Conclusions:
- The timely and appropriate application of MCS is crucial for optimizing patient outcomes.
- A "not too early, not too late" approach, guided by careful monitoring, is essential for successful MCS therapy.
- Multidisciplinary team involvement is vital in selecting patients and managing MCS interventions.
Opinion Statement:
The treatment of cardiovascular failure in the perioperative period with the use of mechanical circulatory support is a well-recognized, well-developed, and commonly utilized treatment modality. Regardless of the exact circumstances of initiation, the use of a support device is a "bridge." Where there has been an acute myocardial insult, short-term assist devices can serve as a "bridge to immediate survival," a "bridge to recovery," or even a "bridge to the next decision." Mechanical circulatory support can serve as a treatment of cardiovascular decompensation caused by myocarditis, acute myocardial insult, low cardiac output following surgery, and congenital heart disease. The utilization of such support carries significant risks such as bleeding, infection, and thrombosis. However, these can be minimized in order to allow for the safe and effective deployment of this therapeutic strategy. One specific therapeutic domain in which these devices provide immediate impact is during cardiac arrest. Although outcomes of cardiac arrest remain poor, use of a mechanical device as an intervention has allowed salvage of otherwise certain mortality. However, it is important to note that the utility of support was most pronounced in patients that were not on either extreme of the survival prediction curve. This can be best summarized by the concept of "not too early, not too late." Therefore, it is the responsibility of the entire care team to find the appropriate patient population in which to "pull the trigger" on mechanical support as a therapy. This decision point is supported by a monitoring strategy that can be utilized to predict deterioration and intervene adequately. Most importantly, an effective monitoring strategy allows the practitioner to judge the effectiveness of treatment and support strategies and make adjustments in a timely manner, potentially with mechanical support in the perioperative period.
