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Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

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Mortality in infants with cardiovascular malformations.

Christopher Wren¹, Claire A Irving, Josephine Amanda Griffiths

¹Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK. christopher.wren@nuth.nhs.uk

European Journal of Pediatrics

|July 13, 2011

Summary

Cardiovascular malformations cause significant infant mortality. While deaths decreased due to increased pregnancy terminations and better surgical outcomes, many infant deaths are still linked to these conditions or their treatments.

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Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

Area of Science:

Pediatrics
Cardiology
Public Health

Background:

Cardiovascular malformations (CVMs) are a leading cause of infant mortality and the primary cause of death from congenital malformations.
Understanding mortality trends and contributing factors is crucial for improving infant survival rates.

Purpose of the Study:

To analyze and categorize infant deaths related to cardiovascular malformations.
To examine mortality trends over time and identify factors influencing these outcomes.

Main Methods:

Data on infant deaths and CVMs were collected from a single health region between 1987 and 2006.
Deaths were categorized by cause, including cardiac and non-cardiac factors, and the presence of chromosomal, genetic, or other malformations.
Pregnancy termination rates and surgical outcomes were also analyzed.

Main Results:

Out of 676,927 live births, 4,437 infants had CVMs, with a 10.3% mortality rate before one year of age.
Non-cardiac causes accounted for 33% of deaths, while cardiac causes (with or without surgery) accounted for 67%.
Pregnancy terminations for CVMs increased significantly over the study period, and 10% of infants undergoing cardiac surgery died before one year.

Conclusions:

Cardiovascular malformations contribute to 10.4% of all infant deaths, with two-thirds of these deaths linked to the malformation itself or its treatment.
Mortality rates have declined, attributed to increased pregnancy terminations and improved post-operative survival rates.