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Intracranial hemorrhage in children with congenital factor deficiencies

Turkan Patiroglu1, Mehmet Akif Ozdemir, Ekrem Unal

  • 1Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Talas, Kayseri, Turkey.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|July 13, 2011
PubMed

Insights

Intracranial hemorrhage (ICH) in children with congenital factor deficiencies (CFD) is serious. Prompt recognition and treatment are key to survival and preventing long-term deficits.

Area of Science:

  • Pediatric Hematology
  • Neurology
  • Genetics

Background:

  • Intracranial hemorrhage (ICH) poses a significant threat to children.
  • Congenital factor deficiencies (CFD) are a known cause of ICH, sometimes presenting as the first symptom.
  • Prompt diagnosis and management are crucial.

Purpose of the Study:

  • To evaluate the incidence, causes, and outcomes of ICH in children with CFD.
  • To identify risk factors and optimal management strategies for ICH in this pediatric population.

Main Methods:

  • A retrospective review of 107 children with CFD from 2000-2010.
  • ICH episodes were identified through clinical evaluation and neuroimaging (CT/MR).
  • Management strategies, surgical interventions, and patient outcomes were analyzed.

Main Results:

  • 18 patients (16.8%) experienced 21 ICH episodes, with a mean age of 42.1 months.
  • Trauma was the leading cause (57.1%), followed by non-trauma related events (42.9%). Epidural hematoma was most common.
  • All patients survived, though four developed intellectual capacity decrease and motor deficits.

Conclusions:

  • Optimal management of ICH in pediatric CFD requires immediate recognition and prompt replacement therapy.
  • Adequate surgical intervention is essential for hemostatic balance and improved outcomes.
  • Early intervention can mitigate long-term neurological sequelae.
Abstract

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