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Updated: May 31, 2026

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell (MSC) Spheroids Primed in 3-D Cultures Under Xeno-free Conditions
Published on: March 18, 2017
Therapeutic factors secreted by mesenchymal stromal cells and tissue repair
Ryang Hwa Lee1, Joo Youn Oh, Hosoon Choi
1Texas A&M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott & White, Temple, Texas 76502, USA. RLee@medicine.tamhsc.edu
Abstract:
Systemic administration of MSCs resulted in remarkable functional improvements in injured tissues without either long-term engraftment or differentiation in many clinical and experimental situations. Emerging evidence suggest that most of the beneficial effects of MSCs could be explained by secretion of soluble factors that have multiple effects including modulation of inflammatory and immune reactions, protection from cell death, and stimulation of endogenous progenitor cells. In this review, we focus on the therapeutic factors that account for the beneficial effects of MSCs in animal models of human diseases.
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