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Updated: May 31, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Synthesis, characterization and DNA binding and cleavage properties of ruthenium(II) complexes with various
Mohan N Patel1, Pradhuman A Parmar, Deepen S Gandhi
1Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India. jeenenpatel@yahoo.co.in
Abstract:
Polypyridyl chlororuthenium(II) complexes have been synthesized and characterized. The binding mode of the complexes to DNA has been evaluated from the combined results of electronic absorption spectroscopy and viscosity measurement study. The results suggest that complexes 1, 2 and 3 bind to DNA via classical intercalation, electrostatic interaction and partial intercalation mode, respectively. Complex 2 shows less affinity for DNA. Cleavage of pUC19 DNA by complexes has been checked using gel electrophoresis. The data disclose that complex 1 has the highest cleaving ability.
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