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Limited agreement between current and long-term asthma control in children: the PACMAN cohort study

Ellen S Koster1, Jan A M Raaijmakers, Susanne J H Vijverberg

  • 1Division of Pharmacoepidemiology & Clinical Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|July 14, 2011
PubMed

Insights

Asthma control assessment varies significantly based on whether current or long-term measures are used. Evaluating asthma control over extended periods is crucial for accurate patient management and treatment effectiveness.

Area of Science:

  • Pediatric Pulmonology
  • Asthma Management
  • Clinical Phenotyping

Background:

  • Predictors of asthma treatment outcomes are influenced by the chosen outcome definition.
  • Distinct asthma control aspects may be reflected by different outcome measures.
  • Establishing firm outcome phenotypes is essential for assessing asthma control predictors.

Purpose of the Study:

  • To investigate the association between current and long-term asthma control measurements.
  • To compare different definitions of asthma control in children using inhaled corticosteroids.

Main Methods:

  • Included 527 children using inhaled corticosteroids from the Pharmacogenetics of Asthma medication in Children cohort.
  • Current asthma control assessed using the Asthma Control Questionnaire (previous week).
  • Long-term asthma control defined by Global Initiative for Asthma guidelines, considering seasonal and yearly data.

Main Results:

  • Long-term uncontrolled asthma rates were highest in autumn/winter (50%) and lowest in summer (32%).
  • Overall agreement between current and long-term asthma control was limited (66-68%).
  • Significant seasonal variations in asthma control were observed.

Conclusions:

  • Limited congruence exists between current and long-term asthma control assessments.
  • Seasonal differences impact asthma control measurements.
  • Calculating asthma control over a longer duration is recommended over relying solely on current indicators.
Abstract

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