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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Related Experiment Video

Updated: May 31, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Caloric restriction and chronic inflammatory diseases.

O A González1, C Tobia, J L Ebersole

  • 1Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington 40536-0305, USA. ogonz2@email.uky.edu

Oral Diseases
|July 14, 2011
PubMed
Summary

Caloric restriction (CR) slows aging and prevents diseases by affecting metabolic pathways. CR mimetics may offer an alternative to control chronic inflammatory disorders like periodontal disease.

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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Related Experiment Videos

Last Updated: May 31, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Area of Science:

  • Gerontology and Metabolic Health
  • Inflammation and Chronic Disease Research

Background:

  • Caloric restriction (CR) consistently reduces biological aging across species.
  • CR protects against age-associated diseases, including cardiovascular disease, diabetes, and chronic inflammatory disorders.
  • Understanding CR's metabolic pathways is key to developing CR mimetics.

Purpose of the Study:

  • To review the concepts of CR and CR mimetics.
  • To discuss the effects of CR and mimetics on inflammation and chronic inflammatory diseases.
  • To present evidence on CR's impact on periodontal disease in primates.

Main Methods:

  • Literature review of studies on caloric restriction.
  • Analysis of research on CR mimetics and their molecular targets.
  • Examination of evidence linking CR to inflammation and specific diseases, including periodontal disease.

Main Results:

  • CR demonstrably decreases the rate of biological aging and mitigates age-related diseases.
  • CR influences key metabolic pathways, sparking interest in pharmacological mimetics.
  • Emerging data suggests CR's beneficial effects on periodontal disease in non-human primates.

Conclusions:

  • CR mimetics present a potential strategy for managing chronic inflammatory disorders.
  • CR mimetics could be a viable alternative for preventing diseases, especially given societal challenges with dietary CR.
  • Further research into CR mimetics may offer novel therapeutic approaches for inflammatory conditions and periodontal disease.