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Caloric restriction and chronic inflammatory diseases

O A González1, C Tobia, J L Ebersole

  • 1Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington 40536-0305, USA. ogonz2@email.uky.edu

Oral Diseases
|July 14, 2011
PubMed

Insights

Caloric restriction (CR) slows aging and prevents diseases by affecting metabolic pathways. CR mimetics may offer an alternative to control chronic inflammatory disorders like periodontal disease.

Area of Science:

  • Gerontology and Metabolic Health
  • Inflammation and Chronic Disease Research

Background:

  • Caloric restriction (CR) consistently reduces biological aging across species.
  • CR protects against age-associated diseases, including cardiovascular disease, diabetes, and chronic inflammatory disorders.
  • Understanding CR's metabolic pathways is key to developing CR mimetics.

Purpose of the Study:

  • To review the concepts of CR and CR mimetics.
  • To discuss the effects of CR and mimetics on inflammation and chronic inflammatory diseases.
  • To present evidence on CR's impact on periodontal disease in primates.

Main Methods:

  • Literature review of studies on caloric restriction.
  • Analysis of research on CR mimetics and their molecular targets.
  • Examination of evidence linking CR to inflammation and specific diseases, including periodontal disease.

Main Results:

  • CR demonstrably decreases the rate of biological aging and mitigates age-related diseases.
  • CR influences key metabolic pathways, sparking interest in pharmacological mimetics.
  • Emerging data suggests CR's beneficial effects on periodontal disease in non-human primates.

Conclusions:

  • CR mimetics present a potential strategy for managing chronic inflammatory disorders.
  • CR mimetics could be a viable alternative for preventing diseases, especially given societal challenges with dietary CR.
  • Further research into CR mimetics may offer novel therapeutic approaches for inflammatory conditions and periodontal disease.

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