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Cytotoxic sesquiterpenoids from the fruits of Lindera communis
Zhipeng Deng1, Hao Zhong, Shuxiang Cui
1Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, 250062, China.
Fitoterapia
|July 14, 2011
Abstract:
A new sesquiterpenoid, namely Linerenone (1), together with three known sesquiterpenoids (2-4), were isolated from the fruits of Lindera communis. Their structures were determined by extensive spectroscopic analysis including 1D, 2D-NMR and HR-MS spectra. Compound 1 showed significant cytotoxic activity against H460, ES2 and DU145 cancer cells with IC(50) of 2.1 μg/mL, 2.8 μg/mL and 3.0 μg/mL, respectively.