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Updated: May 31, 2026
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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Improved survival after pulmonary metastasectomy for soft tissue sarcoma
Jarrod D Predina1, Matthew M Puc, Meredith R Bergey
1Division of Thoracic Surgery, Joan Karnell Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Summary
Survival rates for soft tissue sarcoma (STS) pulmonary metastasectomy have improved significantly. Better patient selection, not chemotherapy, appears to be the key factor in this enhanced survival outcome.
Area of Science:
- Oncology
- Surgical Oncology
- Sarcoma Research
Background:
- Pulmonary metastasectomy for soft tissue sarcoma (STS) historically shows lower survival rates compared to osteosarcoma.
- Recent advancements in patient selection and chemotherapy prompted a re-evaluation of STS outcomes.
Purpose of the Study:
- To investigate whether survival rates after pulmonary metastasectomy for STS have improved in recent years.
- To identify predictors of overall survival and disease-free survival (DFS) in STS patients undergoing metastasectomy.
Main Methods:
- Retrospective analysis of 48 STS patients who underwent pulmonary metastasectomy (1995-2007).
- Log-rank test and Cox regression used to analyze predictors of overall survival and DFS.
- Multivariate analysis performed using Cox regression.
Main Results:
- Five-year overall survival was 52%, a significant improvement over historical data (14-40%).
- Fewer than three pulmonary metastases, largest metastasis diameter ≤2 cm, and absence of extrapulmonary metastases were associated with longer survival.
- No significant association found between adjuvant chemotherapy use/type and survival outcomes.
Conclusions:
- Five-year overall survival after STS pulmonary metastasectomy has substantially improved.
- This improvement is likely attributable to enhanced patient selection rather than changes in chemotherapy regimens.
- Further research into optimal patient selection criteria for pulmonary metastasectomy in STS is warranted.
