Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 31, 2026

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

DNA detection with a polymeric nanochannel device.

Paola Fanzio1, Valentina Mussi, Chiara Manneschi

  • 1Nanomed Labs, Dipartimento di Fisica, Università di Genova, via Dodecaneso 33, 16146 Genova, Italy. paola.fanzio@iit.it

Lab on a Chip
|July 14, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Raman mapping on Ag-covered nanostructured substrates as an innovative approach for rapid estimation of post-mortem interval on human whole blood.

International journal of legal medicine·2026
Same author

Fever in a palliative care setting: Clinical insights and implications from a prospective observational cohort study.

Palliative medicine·2026
Same author

Lactate-mediated NK cell dysfunction as a prognostic marker and therapeutic target in breast cancer.

Cell death discovery·2026
Same author

Antisecretory Factor in rat cerebellar granule cells augments inhibitory current via GABA<sub>A</sub> receptors: a mechanism for vertigo reduction in Menière's disease?

European biophysics journal : EBJ·2026
Same author

Applications of Raman spectroscopy in the post-mortem interval estimation: a systematic literature review.

International journal of legal medicine·2026
Same author

Dominant Action of <i>CLCN4</i> Neurodevelopmental Disease Variants in Heteromeric Endosomal ClC-3/ClC-4 Transporters.

Cells·2025

We developed a low-cost, low-noise polymeric nanochannel device for single-molecule analysis. This elastomeric device enables the study of DNA translocation events using electrophoresis, offering an accessible tool for scientific research.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biophysics

Background:

  • Single-molecule analysis requires precise tools for observing molecular behavior.
  • Existing fabrication methods for nanochannel devices can be complex and expensive.
  • Polymeric materials offer potential for low-cost and flexible device fabrication.

Purpose of the Study:

  • To develop and characterize a novel polymeric nanochannel device.
  • To investigate the feasibility of using soft lithography for nanochannel fabrication.
  • To assess the device's performance in studying DNA translocation events.

Main Methods:

  • Fabrication of a silicon master using microfabrication and Focused Ion Beam (FIB) nanofabrication.
  • Replication of the master in a polymeric material via soft lithography.

More Related Videos

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
07:16

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Related Experiment Videos

Last Updated: May 31, 2026

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
07:16

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

  • Electrical characterization of the polymeric nanochannel device.
  • Electrophoresis experiments to study DNA translocation.

    • Main Results:

    • Successful fabrication of an elastomeric nanochannel device using a cost-effective technique.
    • Demonstration of low-noise electrical characteristics suitable for single-molecule analysis.
    • Observation of DNA translocation events within the nanochannel.

    Conclusions:

    • An easy and low-cost fabrication method for polymeric nanochannel devices has been established.
    • The developed device is suitable for low-noise, single-molecule analysis, specifically for DNA translocation studies.
    • Soft lithography provides a viable route for producing advanced nanochannel devices for biophysical research.