Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell Type-Specific Proteomic Cargo in Human Brain Endothelial, Astrocyte, and Neuronal Extracellular Vesicles.

Proteomes·2026
Same author

Global epidemiological trend of cancer incidence and death in adults aged 60 years and older: a systematic analysis of data from GLOBOCAN 2022 and GBD2021.

BMC geriatrics·2025
Same author

Gold-Silver Nanoshell-Embedded Polydimethylsiloxane Films for Near-Infrared Photothermal Eradication of Bacteria.

ACS applied materials & interfaces·2025
Same author

Automatic detection of lucky bamboo nodes based on Improved YOLOv7.

Frontiers in plant science·2025
Same author

Alterations in Tear Proteomes of Adults with Pre-Diabetes and Type 2 Diabetes Mellitus but Without Diabetic Retinopathy.

Proteomes·2025
Same author

Impact of environmental regulation on the supply of ecological products in China: Theoretical analysis based on dynamic game and empirical test.

Journal of environmental management·2025

Related Experiment Video

Updated: May 31, 2026

Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium
12:38

Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium

Published on: December 16, 2011

Click chemistry-based functionalization on non-oxidized silicon substrates.

Yan Li1, Chengzhi Cai

  • 1Department of Chemistry & Center for Materials Chemistry, University of Houston, Houston, Texas 77204, USA.

Chemistry, an Asian Journal
|July 14, 2011
PubMed
Summary
This summary is machine-generated.

Copper-catalyzed azide-alkyne cycloaddition (CuAAC) enables efficient modification of silicon surfaces for biomolecule immobilization. This review highlights "clickable" silicon platforms and their use in developing silicon-based biosensors and molecular electronics.

More Related Videos

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

Light Enhanced Hydrofluoric Acid Passivation: A Sensitive Technique for Detecting Bulk Silicon Defects
09:15

Light Enhanced Hydrofluoric Acid Passivation: A Sensitive Technique for Detecting Bulk Silicon Defects

Published on: January 4, 2016

Related Experiment Videos

Last Updated: May 31, 2026

Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium
12:38

Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium

Published on: December 16, 2011

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

Light Enhanced Hydrofluoric Acid Passivation: A Sensitive Technique for Detecting Bulk Silicon Defects
09:15

Light Enhanced Hydrofluoric Acid Passivation: A Sensitive Technique for Detecting Bulk Silicon Defects

Published on: January 4, 2016

Area of Science:

  • Materials Science
  • Surface Chemistry
  • Biotechnology

Background:

  • Silicon substrates are crucial for electronics and sensors.
  • Modifying silicon surfaces with biomolecules is challenging.
  • Copper-catalyzed azide-alkyne cycloaddition (CuAAC) offers a robust conjugation strategy.

Purpose of the Study:

  • To review recent advances in preparing clickable silicon platforms.
  • To discuss the derivatization of these platforms using CuAAC.
  • To highlight the application of functionalized surfaces in biosensing and molecular electronics.

Main Methods:

  • Preparation of alkynyl- or azido-terminated organic layers on non-oxidized silicon.
  • Utilizing the CuAAC reaction for surface functionalization.
  • Characterization of the resulting click-functionalized organic thin films.

Main Results:

  • Demonstrated efficient methods for creating clickable silicon surfaces.
  • Showcased successful immobilization of complex biomolecules via CuAAC.
  • Established these surfaces as valuable models for studying biological events.

Conclusions:

  • CuAAC is a powerful tool for silicon surface modification and biomolecule attachment.
  • Click-functionalized silicon surfaces are promising for advanced molecular electronics and chemical/biomolecular sensors.
  • This approach facilitates the development of next-generation silicon-based devices.