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Related Concept Videos

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Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
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Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
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Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Renal Drug Excretion: Glomerular Filtration01:02

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The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Drug Elimination by Renal Route: Glomerular Filtration01:17

Drug Elimination by Renal Route: Glomerular Filtration

The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production takes place. A nephron has two main components: a renal corpuscle and a renal tubule. Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent...

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Mycophenolate mofetil in primary glomerular diseases.

Jacob George1

  • 1Medical College, Thiruvananthapuram.

The Journal of the Association of Physicians of India
|July 15, 2011
PubMed
Summary
This summary is machine-generated.

Mycophenolate mofetil offers a promising treatment for primary glomerular diseases, showing fewer side effects and no nephrotoxicity compared to other immunosuppressants. This review explores its efficacy in managing these complex kidney conditions.

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Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Primary glomerular diseases present treatment challenges due to variability, drug resistance, relapses, and toxicity.
  • Current immunosuppressive therapies lack a clear superior agent for these conditions.

Purpose of the Study:

  • To review the recent literature on the efficacy of mycophenolate mofetil in managing primary glomerular diseases.
  • To highlight the potential advantages of mycophenolate mofetil, including reduced side effects and absence of nephrotoxicity.

Main Methods:

  • Literature review of recent studies.
  • Analysis of clinical data on mycophenolate mofetil use in primary glomerular diseases.

Main Results:

  • Mycophenolate mofetil has demonstrated some superiority in related conditions like lupus nephritis and renal transplantation.
  • The drug exhibits a favorable side effect profile with no observed nephrotoxicity.

Conclusions:

  • Mycophenolate mofetil is a potential therapeutic option for primary glomerular diseases.
  • Its reduced toxicity and efficacy warrant further investigation in managing these kidney disorders.