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Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

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Mixed Reality Assisted Radical Endoscopic Thyroidectomy
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Published on: January 31, 2025

Trauma precipitating thyroid storm.

Girish R Sabnis1, Niteen D Karnik, Swati A Chavan

  • 1Department of Medicine, LTM Medical College and LTMG Hospital, Sion, Mumbai-400022.

The Journal of the Association of Physicians of India
|July 15, 2011
PubMed
Summary
This summary is machine-generated.

Trauma can trigger thyrotoxic crisis, a rare but serious condition. Prompt diagnosis and treatment are crucial for patient recovery from this medical emergency.

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Area of Science:

  • Emergency Medicine
  • Endocrinology
  • Trauma Surgery

Background:

  • Thyrotoxic crisis is a life-threatening exacerbation of thyrotoxicosis.
  • Trauma is an uncommon but recognized precipitant of thyrotoxic crisis.
  • This case highlights the importance of considering endocrine emergencies in trauma patients.

Observation:

  • A 40-year-old male with multiple limb injuries from a road traffic accident presented with a normal Glasgow Coma Score (GCS).
  • Post-admission, the patient developed confusion, stupor, fever, and tachycardia.
  • Clinical presentation suggested a thyroid storm superimposed on trauma.

Findings:

  • Investigations confirmed the diagnosis of thyrotoxic crisis.
  • The patient responded well to appropriate therapeutic interventions.
  • This case represents a rare instance of trauma-induced thyrotoxic crisis.

Implications:

  • Clinicians should maintain a high index of suspicion for thyrotoxic crisis in trauma patients presenting with altered mental status and autonomic instability.
  • Early recognition and management are vital for improving outcomes in this rare condition.
  • Further research into the pathophysiology and management strategies for trauma-precipitated thyrotoxic crisis is warranted.