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Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: May 31, 2026

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

[Epi-Lasek--our experience].

T Ml Juhás¹, T Juhás

¹Ocná klinika LF UPJS a UNLP, Kosice. juhastomas@yahoo.com

Ceska a Slovenska Oftalmologie : Casopis Ceske Oftalmologicke Spolecnosti a Slovenske Oftalmologicke Spolecnosti

|July 15, 2011

Summary

Alcohol-assisted epithelial flap creation using Epi-Lasek significantly improves outcomes in excimer laser refractive surgery. This method enhances flap creation and separation, leading to optimal conditions for laser ablation and better visual acuity.

Area of Science:

Ophthalmology
Laser Surgery

Context:

Refractive surgery aims to correct vision errors.
Excimer laser surface ablation is a common refractive procedure.
Epithelial flap creation is a critical step in some refractive surgeries.

Purpose:

To evaluate the advantages of using alcohol for epithelial flap creation in Epi-Lasek.
To assess the efficacy and safety of alcohol-assisted epithelial flap creation prior to excimer laser ablation.

Summary:

This study involved 100 eyes undergoing Epi-Lasek with 20% alcohol for epithelial flap creation.
Preoperative spherical equivalent averaged -3.44 D.
Postoperative uncorrected visual acuity at 1 month was 0.8-1.0 in 92% of eyes.
At 12 months, mean spherical equivalent was -0.262 D with no observed haze.

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Impact:

Alcohol-assisted epithelial flap creation in Epi-Lasek is a valuable contribution to refractive surgery.
This technique enhances epithelial flap creation and separation.
It preserves the epithelial basal membrane, creating optimal conditions for excimer laser ablation.