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Updated: May 31, 2026
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
Bioinspired choline-like ionic liquids: their penetration ability through cell membranes and application to SEM
Koji Kawai1, Kotaro Kaneko, Hayato Kawakami
1Division of Materials Science and Engineering, Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-Ku, Sapporo, Hokkaido 060-8628, Japan.
Abstract:
This letter proposes the use of choline-like hydrophilic ionic liquids (ILs) to visualize hydrous samples (e.g., seaweed and other biological or food samples) for scanning electron microscopy (SEM) observation. Some of the water in the samples was successfully replaced with these ILs, which penetrated the cell membranes. The treated samples did not contract much even after drying. The ILs' ionic conductivity decreased the charging of sample surfaces, and good SEM images were obtained.
