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Neuropective constituents from the rhizomes of Abacopteris penangiana

Han Wei1, Guang-Hua Wu, Yong-Fang Lei

  • 1Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, Tongji Medical Center, College of Pharmacy, Huazhong University of Science and Technology, Wuhan, China.

Journal of Asian Natural Products Research
|July 15, 2011
PubMed

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Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...