Related Experiment Video

Updated: May 31, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Genotypes of rotavirus associated with acute gastroenteritis in Seoul, Korea

Sanghun Park1, Seah Oh, Jibho Lee

  • 1Virus Team, Seoul Metropolitan Government Research Institute of Public Health and Environment, 202-3 Yangjae-Dong, Seocho-Gu, Seoul 137-734, Korea. sanghun93@seoul.go.kr

Microbiology and Immunology
|July 15, 2011
PubMed

Insights

Rotavirus, a common cause of infant gastroenteritis, was studied in Seoul, Korea. The most frequent G-P type detected was G1P[8], providing key data for rotavirus disease control.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Acute viral gastroenteritis is a leading cause of illness in young children globally.
  • Rotavirus is a primary pathogen responsible for severe gastroenteritis in infants and children.
  • Understanding rotavirus epidemiology, including genotypes, is crucial for disease prevention and control.

Purpose of the Study:

  • To determine the detection rate, seasonality, and G and P genotypes of rotaviruses in hospitalized children with acute gastroenteritis in Seoul, Korea.
  • To establish baseline data for rotavirus surveillance and inform public health strategies.
  • To identify the predominant rotavirus strains circulating in the study population.

Main Methods:

  • A total of 1,423 stool specimens were collected from children hospitalized for acute gastroenteritis in Seoul, Korea, during 2009.
  • Enzyme-linked immunosorbent assay (ELISA) was used to screen for rotavirus antigens.
  • Reverse transcription-polymerase chain reaction (RT-PCR) was employed for rotavirus genotyping (G and P types).

Main Results:

  • Rotavirus was detected in a significant proportion of hospitalized children with acute gastroenteritis.
  • The most prevalent G-P genotype combination identified was G1P[8], accounting for 38.3% of cases.
  • Other G-P combinations, including G4P[6] (5.9%), were also detected, indicating genotypic diversity.

Conclusions:

  • The study provides essential epidemiological data on rotavirus strains circulating in Seoul, Korea, in 2009.
  • The findings highlight the importance of G1P[8] as a dominant rotavirus genotype in pediatric gastroenteritis.
  • This baseline information is vital for motivating the implementation of rotavirus vaccination and other control measures.

More Related Videos

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...