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Updated: May 31, 2026

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Synthesis and antiglycation potentials of bergenin derivatives
T Vijaya Kumar1, Ashok K Tiwari, A Robinson
1Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500607, India.
Abstract:
Bergenin (1), major bioactive compound isolated from methanolic extract of Mallotus philippinensis, displayed moderate AGE inhibition activity (IC(50)=186.73 μM). A series of derivatives of bergenin (3a-k) containing variety of aromatic acids were synthesized under mild conditions by modification of sugar part. Selective esterification of hydroxyl groups on the sugar part enhanced antiglycation potential of bergenin. Compounds 3j and 3k exhibited potent antiglycation activity with the IC(50) values of 60.75 and 12.28 μM, respectively.
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