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Updated: May 31, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

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Late preterm birth: can be reduced.

Cynthia Gyamfi Bannerman¹

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.

American Journal of Obstetrics and Gynecology

|July 15, 2011

Summary

This summary is machine-generated.

Late preterm births (34-36 weeks) are increasing and linked to higher infant mortality. While reducing these births is important, evidence for extending pregnancies is insufficient.

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Area of Science:

Neonatal Medicine
Obstetrics
Public Health

Background:

Late preterm birth (34-36 weeks) is defined and has seen a 15% increase between 1992-2002.
This birth timing affects 8% of singletons and 35% of multiple gestations.
Late preterm infants face higher risks of respiratory distress, pneumonia, ventilation needs, and mortality compared to full-term infants.

Purpose of the Study:

To highlight the rising incidence of late preterm births.
To underscore the associated neonatal and infant morbidity and mortality risks.
To emphasize the need for caution regarding interventions aimed at prolonging these pregnancies due to insufficient evidence of improved outcomes.

Main Methods:

Analysis of birth data trends.
Comparison of morbidity and mortality rates between late preterm and full-term infants.
Review of evidence regarding the benefits of prolonging late preterm pregnancies.

Main Results:

Late preterm births have increased significantly, particularly in multiple gestations.
Late preterm infants exhibit substantially higher rates of respiratory distress syndrome, pneumonia, need for ventilation, and mortality.
Current evidence is insufficient to support interventions that prolong pregnancies in this group to improve maternal-fetal outcomes.

Conclusions:

Reducing the rate of late preterm birth is a public health priority.
Despite increased risks, caution is advised when considering interventions to prolong late preterm pregnancies.
Further research is needed to establish evidence-based strategies for optimizing outcomes in late preterm births.