Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development and validation of commissioning tests for volumetric modulated arc therapy on the 1.5T MR-linac.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026

Same author

First Patient Study With Visual Biofeedback for Gating Delivery Efficiency Improvements on a 1.5 T MR-Linac.

International journal of radiation oncology, biology, physics·2026

Same author

Bowel tracking for MR-guided radiotherapy: simultaneous optimization of small bowel imaging and tracking.

Physics in medicine and biology·2025

Same author

Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708).

Clinical and translational radiation oncology·2025

Same author

Robust deep learning-based forward dose calculations for VMAT on the 1.5T MR-linac.

Physics in medicine and biology·2022

Same author

Dosimetric evaluation of off-axis fields and angular transmission for the 1.5 T MR-linac.

Physics in medicine and biology·2022

Search research articles

Related Experiment Video

Updated: May 31, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Towards MRI-guided linear accelerator control: gating on an MRI accelerator.

S P M Crijns¹, J G M Kok, J J W Lagendijk

¹Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. s.crijns@umcutrecht.nl

Physics in Medicine and Biology

|July 15, 2011

Summary

This study demonstrates real-time MRI-guided radiation therapy, enabling precise gating for abdominal cancer treatment. This integrated system accurately tracks motion, delivering sharp radiation doses and paving the way for adaptive radiotherapy.

More Related Videos

Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain

Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain

Published on: March 31, 2023

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Management of Respiratory Motion Artefacts in ¹⁸F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

Related Experiment Videos

Last Updated: May 31, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain

Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain

Published on: March 31, 2023

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Management of Respiratory Motion Artefacts in ¹⁸F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

Area of Science:

Medical Physics
Radiotherapy Technology
Medical Imaging

Background:

Respiration-induced motion significantly complicates abdominal radiotherapy.
Current motion compensation strategies like gating and tracking benefit from direct visualization of anatomy.
Integrating Magnetic Resonance Imaging (MRI) with a linear accelerator (LINAC) offers superior soft-tissue contrast for enhanced image guidance.

Purpose of the Study:

To develop and validate an infrastructure for MRI-guided gated radiation delivery.
To demonstrate the feasibility of real-time motion tracking and feedback for radiotherapy.
To establish a foundation for advanced MRI-guided LINAC functionalities.

Main Methods:

Tracking a phantom's motion using an integrated MRI scanner.
Establishing real-time communication between the MRI scanner and LINAC controls.
Implementing gated radiation delivery based on time-resolved phantom position data.
Recording dose distributions using gafchromic film for varying gating window sizes.

Main Results:

Successful real-time tracking and gated radiation delivery to a moving phantom.
Achieved sharp dose profiles with a 5 mm gating window, closely matching theoretical profiles.
Demonstrated the capability for real-time, on-line accumulated dose reconstruction.
Validated the gating implementation through excellent correspondence between measured and theoretical dose profiles.

Conclusions:

The developed infrastructure enables effective MRI-guided gated radiotherapy.
Real-time dose reconstruction facilitates adaptive treatment planning within a single fraction.
This work represents a significant step towards advanced, integrated MRI-LINAC systems for improved cancer treatment.