Polymeric strontium ranelate nona-hydrate

Area of Science:

• Crystal chemistry
• Materials science
• Coordination chemistry

Background:

• Strontium ranelate is a compound with pharmaceutical applications.
• Understanding the crystal structure of metal-organic frameworks (MOFs) is crucial for materials design.

Purpose of the Study:

• To elucidate the detailed crystal structure of a novel strontium ranelate-based metal-organic framework.
• To investigate the coordination environment of strontium cations and the role of water molecules.

Main Methods:

• Single-crystal X-ray diffraction analysis was employed.
• The crystal structure was solved and refined to determine atomic positions and coordination geometries.

Main Results:

• The compound crystallizes as a metal-organic framework with nine- and eight-coordinated Sr(2+) cations.
• The structure exhibits hollow layers connected by ranelate anions, forming channels along the a axis.
• Water molecules are present both in the coordination sphere and in the channels, with some disorder observed.

Conclusions:

• The strontium ranelate compound forms a stable MOF structure with channels amenable to guest molecules.
• The presence and disorder of water molecules significantly impact the overall crystal structure and its dehydration behavior.