Related Experiment Video
Updated: May 31, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
(OC-6-35)-(2,2'-Bipyridine-κN,N')dimeth-yl(3-sulfido-propionato-κS,O)platinum(IV)
Matthew S McCready1, Richard J Puddephatt
1Department of Chemistry, University of Western Ontario, London, Canada N6A 5B7.
Abstract:
The title complex, [Pt(CH(3))(2)(SCH(2)CH(2)CO(2))(C(10)H(8)N(2))], is formed by the unusual oxidative addition of the disulfide, R(2)S(2) (R = CH(2)CH(2)CO(2)H), to (2,2'-bipyridine)-dimethyl-platin-um(II) with elimination of RSH. The product contains an unusual six-membered thiol-ate-carboxyl-ate chelate ring. This slightly distorted octa-hedral complex exhibits cis angles ranging from 77.55 (11) to 97.30 (8)° due to the presence of the thiol-ate-carboxyl-ate chelate ring and the constrained bipyridine group. The crystal packing appears to be controlled by a combination of π-stacking [centroid-centroid distance = 3.611 (2) Å] and C-H⋯O inter-actions.
Related Concept Videos
Preparation and Reactions of Sulfides
Properties of Organometallic Compounds
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Hybridization of Atomic Orbitals II
Coordination Compounds and Nomenclature
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

