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Related Concept Videos

Acidity and Basicity of Alcohols and Phenols02:36

Acidity and Basicity of Alcohols and Phenols

Like water, alcohols are weak acids and bases. This is attributed to the polarization of the O–H bond making the hydrogen partially positive. Moreover, the electron pairs on the oxygen atom of alcohol make it both basic and nucleophilic. Protonation of an alcohol converts hydroxide, a poor leaving group, into water—a good one. The two acid–base equilibria corresponding to ethanol are depicted below.
Structure and Nomenclature of Alcohols and Phenols02:23

Structure and Nomenclature of Alcohols and Phenols

Overview
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...
Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis02:29

Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis

Overview
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.

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Related Experiment Video

Updated: May 31, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

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Published on: February 7, 2019

2,2,2-Tris(pyrazol-1-yl)ethanol.

Craig C McLauchlan1, Brigette L Smith, Reyhana S Pippins

  • 1Department of Chemistry, Illinois State University, Campus Box 4160, Normal, IL 61790-4160, USA.

Acta Crystallographica. Section E, Structure Reports Online
|July 15, 2011
PubMed
Summary

The novel compound TPE was synthesized and characterized. Its crystal structure reveals intermolecular hydrogen bonding involving the pyrazole ring.

Area of Science:

  • Crystallography
  • Organic Chemistry
  • Materials Science

Background:

  • The synthesis of novel organic compounds is crucial for advancing chemical knowledge.
  • Understanding intermolecular interactions aids in predicting material properties.

Purpose of the Study:

  • To synthesize and characterize the title compound, TPE (C11H12N6O).
  • To investigate the crystal structure and intermolecular interactions of TPE.

Main Methods:

  • Slow evaporation from diethyl ether was employed for crystal preparation.
  • X-ray crystallography was used to determine the molecular and crystal structure.

Main Results:

  • The compound TPE, C11H12N6O, was successfully synthesized.

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Published on: August 22, 2018

  • Analysis of the crystal structure revealed a significant hydrogen bond.
  • This hydrogen bond occurs between an alcohol hydrogen atom and a nitrogen atom within the pyrazole ring of an adjacent molecule.

    • Conclusions:

    • The synthesis of TPE was achieved.
    • The crystal structure confirms the presence of specific intermolecular hydrogen bonding, offering insights into its solid-state behavior.