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Updated: May 31, 2026
14:18
A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
3-(7-Meth-oxy-β-carbolin-1-yl)propionic acid monohydrate.
Summary
This study details the crystal structure of 3-(7-methoxy-9H-pyrido[3,4-b]indol-1-yl)propanoic acid monohydrate. The compound exhibits unique hydrogen bonding interactions involving water molecules and the carboxyl group.
Area of Science:
- Crystallography
- Organic Chemistry
- Materials Science
Background:
- Pyrido[3,4-b]indole derivatives are known for their diverse biological activities.
- Understanding the solid-state structure is crucial for drug design and material properties.
Purpose of the Study:
- To elucidate the crystal structure of 3-(7-methoxy-9H-pyrido[3,4-b]indol-1-yl)propanoic acid monohydrate.
- To investigate the hydrogen bonding network within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction analysis was performed.
- The crystal structure was solved and refined.
Main Results:
- The fused ring system shows minimal dihedral angles, indicating a nearly planar structure.
- The water molecule participates in three distinct hydrogen-bonded chains (O-H⋯O and N-H⋯O).
- The carboxyl group forms an intermolecular O-H⋯N hydrogen bond.
Conclusions:
- The crystal packing is stabilized by an extensive hydrogen bond network.
- The structural data provides insights into the intermolecular interactions of this pyrido[3,4-b]indole derivative.
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