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Updated: May 31, 2026
08:43
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-Meth-oxy-N'-(4-meth-oxy-benzyl-idene)benzohydrazide
1College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, People's Republic of China.
Summary
Researchers synthesized a novel organic compound, C(16)H(16)N(2)O(3), using readily available precursors. Crystal analysis revealed a specific dihedral angle and intermolecular hydrogen bonding forming chains.
Area of Science:
- Organic Chemistry
- Crystallography
- Supramolecular Chemistry
Background:
- The synthesis and structural characterization of novel organic compounds are fundamental to advancing materials science and medicinal chemistry.
- Understanding intermolecular interactions, such as hydrogen bonding, is crucial for predicting and controlling crystal packing and material properties.
Purpose of the Study:
- To synthesize and characterize a new organic compound with the molecular formula C(16)H(16)N(2)O(3).
- To investigate the crystal structure, including the dihedral angle between aromatic rings and intermolecular interactions.
Main Methods:
- Chemical synthesis involving the reaction of 4-methoxy-benzaldehyde with 4-methoxy-benzohydrazide in methanol.
- Single-crystal X-ray diffraction analysis to determine the molecular and crystal structure.
Main Results:
- Successful synthesis of the target compound C(16)H(16)N(2)O(3).
- The crystal structure exhibits a dihedral angle of 3.1(3)° between the two benzene rings.
- Intermolecular N-H⋯O hydrogen bonds were identified, leading to the formation of C(4) chains along the b axis.
Conclusions:
- The study successfully prepared and structurally elucidated a new organic compound.
- The observed dihedral angle and hydrogen bonding patterns provide insights into the molecule's solid-state organization.
- The findings contribute to the understanding of structure-property relationships in organic crystals.
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