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Neoline from Aconitum flavum Hand.

Wei Liu1, Xiong-Jun Gou, Qin Song

  • 1Faculty of Biotechnology Industry, Chengdu University, Chengdu 610016, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|July 15, 2011
PubMed
Summary

Researchers identified a novel C(19)-diterpenoid alkaloid from Aconitum flavum roots. This compound features a complex aconitane skeleton with specific ring conformations and hydrogen bonding interactions.

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Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Pharmacognosy

Background:

  • Aconitum species are known sources of bioactive alkaloids.
  • Aconitum flavum Hand. is a plant species with potential for novel compound discovery.
  • Diterpenoid alkaloids possess complex chemical structures and diverse biological activities.

Purpose of the Study:

  • To isolate and characterize a novel diterpenoid alkaloid from Aconitum flavum.
  • To elucidate the chemical structure and stereochemistry of the isolated compound.
  • To investigate the structural features and potential interactions of the molecule.

Main Methods:

  • Isolation of the title compound from the roots of Aconitum flavum.
  • Spectroscopic analysis (NMR, MS) for structural elucidation.
  • X-ray crystallography for determining the three-dimensional structure and conformation.

Main Results:

  • A novel C(19)-diterpenoid alkaloid, (1α,6α,14α,16β)-N-ethyl-6,16-dimethoxy-4-methoxymethylaconitane-1,8,14-triol (C(24)H(39)NO(6)), was isolated and identified.
  • The molecule possesses an aconitane carbon skeleton comprising four six-membered and two five-membered rings.
  • Detailed analysis revealed specific ring conformations (envelope, chair, boat) and the presence of intra- and inter-molecular hydrogen bonds.
  • A methyl group exhibited disorder in the crystal structure.

Conclusions:

  • The study successfully isolated and characterized a new diterpenoid alkaloid from Aconitum flavum.
  • The detailed structural analysis provides insights into the molecular architecture and potential chemical properties of this natural product.
  • The findings contribute to the understanding of Aconitum alkaloid diversity and chemical complexity.