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Related Concept Videos

Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Preparation of 1° Amines: Gabriel Synthesis01:28

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Preparation of Amides01:29

Preparation of Amides

Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.

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Synthesis of High Purity Nonsymmetric Dialkylphosphinic Acid Extractants
12:06

Synthesis of High Purity Nonsymmetric Dialkylphosphinic Acid Extractants

Published on: October 19, 2017

N,P,P-Triisopropyl-phosphinic amide.

Normen Peulecke1, Bhaskar R Aluri, Bernd H Müller

  • 1Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Strasse 29A, 18059 Rostock, Germany.

Acta Crystallographica. Section E, Structure Reports Online
|July 15, 2011
PubMed
Summary
This summary is machine-generated.

The synthesis of a novel phosphorus-nitrogen-oxygen compound, C(9)H(22)NOP, was achieved through controlled oxidation. This study reveals the formation of an intermolecular hydrogen bond in its crystalline structure.

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Area of Science:

  • Organometallic Chemistry
  • Inorganic Chemistry
  • Crystallography

Background:

  • Phosphorus-nitrogen compounds are versatile building blocks in synthesis.
  • Understanding intermolecular interactions is crucial for material design.

Purpose of the Study:

  • To synthesize and characterize a new organophosphorus compound.
  • To investigate the structural properties and intermolecular interactions in the solid state.

Main Methods:

  • Slow diffusion of oxygen into a toluene solution of diisopropylaminodiisopropylphosphine ((i)Pr(2)PNH(i)Pr).
  • Single-crystal X-ray diffraction analysis to determine molecular and crystal structure.

Main Results:

  • Successful synthesis of the title compound, C(9)H(22)NOP.
  • Identification of an intermolecular N-H⋯O hydrogen bond in the crystal lattice.
  • Detailed structural analysis revealing bond lengths, angles, and molecular packing.

Conclusions:

  • The compound C(9)H(22)NOP can be readily synthesized under mild oxidative conditions.
  • The observed hydrogen bond plays a significant role in the crystal packing and stability of the compound.