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Updated: May 31, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Ethyl 3-methyl-2,6-diphenyl-piperidine-1-carboxyl-ate
Sampath Natarajan1, Rita Mathews
1Department of Advanced Technology Fusion, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul-143 701, Republic of Korea.
Abstract:
In the title compound, C(21)H(25)NO(2), the piperidine ring adopts a twisted boat conformation characterized by puckering parameters θ = 89.5 (1) and ϕ = 257.5 (2)°. The phenyl groups are located in equatorial and axial positions on the central piperidine ring, while the methyl group is in an equatorial position. The dihedral angle between the phenyl rings is 49.8 (1)°. An intra-molecular C-H⋯O inter-action occurs. The crystal structure features weak inter-molecular C-H⋯O inter-actions and a stabilizing inter-molecular C-H⋯π contact involving the axial phenyl ring.

