Related Experiment Video

Updated: May 31, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

2-[4-(Diethyl-amino)-benzyl-idene]malono-nitrile

Yi Jing, Luo-Ting Yu

    Acta Crystallographica. Section E, Structure Reports Online
    |July 15, 2011
    PubMed

    More Related Videos

    Production and Testing of Antimicrobial Peptides and Their Mimics10:35

    Production and Testing of Antimicrobial Peptides and Their Mimics

    Published on: April 10, 2026

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors09:45

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

    Published on: April 27, 2017

    Related Concept Videos

    1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism01:37

    1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

    Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
    Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

    Alkylation of β-Diester Enolates: Malonic Ester Synthesis

    Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
    Diazonium Group Substitution: –OH and –H01:19

    Diazonium Group Substitution: –OH and –H

    Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
    Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

    Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

    Naming Amides
    The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
    1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview01:26

    1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview

    Nitrous acid and nitric acids are two types of acids containing nitrogen, among which nitrous acid is weaker than nitric acid. Nitrous acid with a pKa value of 3.37 ionizes in water to give a nitrite ion and the hydronium ion.
    The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...
    Preparation of Nitriles01:12

    Preparation of Nitriles

    One of the common methods to prepare nitriles is the dehydration of amides. This method requires strong dehydrating agents like phosphorous pentoxide or boiling acetic anhydride for converting amides to nitriles. Another reagent namely, thionyl chloride also accomplishes the dehydration of amides, where amide acts as a nucleophile. The first step of the mechanism involves the nucleophilic attack by the amide on the thionyl chloride to form an intermediate. In the next step, the electron pairs...