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Related Concept Videos

Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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Members Made of Elastoplastic Material01:19

Members Made of Elastoplastic Material

The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
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Related Experiment Video

Updated: May 31, 2026

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

Ehlers-Danlos syndrome.

Rajin Choudhury1, Valeriu Revenco, Radu Darciuc

  • 1Universitatea de Stat de Medicina si Farmacie "Nicolae Testemitanu", Department of Cardiology, Bd. Stefan cel Mare si Sfant, 165, Chisinau, MD-2004, Moldova.

BMJ Case Reports
|July 15, 2011
PubMed
Summary

This case study details a 63-year-old man with Ehlers-Danlos syndrome experiencing atrial fibrillation and hypertension. It focuses on diagnosis, management, and improving quality of life for patients with this rare connective tissue disorder.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Ehlers-Danlos syndrome is a group of inherited connective tissue disorders.
  • Patients with Ehlers-Danlos syndrome may present with cardiovascular complications.
  • Atrial fibrillation and arterial hypertension are significant comorbidities.

Purpose of the Study:

  • To present a clinical case of Ehlers-Danlos syndrome with cardiovascular manifestations.
  • To discuss the differential diagnosis and diagnostic criteria for this presentation.
  • To outline management strategies and quality of life improvements.

Main Methods:

  • Case report of a 63-year-old Caucasian male.
  • Review of clinical presentation, diagnostic workup, and treatment.

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A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

  • Focus on non-cardiological aspects relevant to Ehlers-Danlos syndrome.

    • Main Results:

    • The patient presented with atrial fibrillation and arterial hypertension.
    • The case highlights the importance of a multidisciplinary approach.
    • Management strategies were tailored to the patient's specific condition.

    Conclusions:

    • Ehlers-Danlos syndrome requires comprehensive management beyond primary symptoms.
    • Accurate diagnosis and tailored treatment are crucial for patient outcomes.
    • Improving quality of life is a key objective in managing complex cases.