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Related Experiment Video

Updated: May 31, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Aripiprazole-induced seizure: a second case report.

Che-Lin Yueh¹, Sung-Lin Yu, Hsiao-Min Chen

¹Yuli Hospital, Department of Health, No. 448, Chaung-Hua Road, Yuli, Hualien, 98141, Taiwan.

BMJ Case Reports

|July 15, 2011

Summary

This summary is machine-generated.

This report details a case of seizure in a patient with schizophrenia after abrupt medication changes. It highlights the potential risk of aripiprazole-induced seizures, a side effect not widely documented.

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Aripiprazole is a third-generation antipsychotic.
Seizure risk associated with aripiprazole is not well-documented in clinical trials.
Previous case reports suggest a potential link between aripiprazole and seizures.

Purpose of the Study:

To present a case of seizure in a patient with schizophrenia following medication changes.
To corroborate previous findings on aripiprazole-induced seizures.
To emphasize the potential for aripiprazole to induce seizures.

Main Methods:

Case report of a 54-year-old male patient with chronic schizophrenia.
Patient experienced a grand mal seizure after abrupt discontinuation of clozapine and benzodiazepines (BZD) and concurrent reinitiation of aripiprazole due to a clinical error.
Exploration of potential seizure etiologies including medication withdrawal, psychogenic seizures, hyponatraemia, and other medical conditions.

Main Results:

The patient developed a witnessed grand mal seizure.
Standard etiological investigations for the seizure were inconclusive.
The clinical scenario supports the hypothesis of aripiprazole-induced seizure.

Conclusions:

Aripiprazole may be associated with an increased risk of seizures, even in the absence of other clear causes.
This case adds to the evidence suggesting aripiprazole-induced seizures.
Clinicians should be aware of this potential adverse effect when prescribing aripiprazole, particularly in patients with complex medication histories or risk factors for seizures.