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Updated: May 31, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Side effects of evidence-based medicine
Antoine Fremault1, Daniel Rodenstein
1Clinique Saint-Joseph, Pneumology, Rue de la Duchere 6, Gilly, 6060, Belgium.
Routine preoperative chest imaging may miss serious conditions in "asymptomatic" patients. Limiting these exams can lead to delayed diagnosis of critical diseases like tuberculosis and lung cancer.
Area of Science:
- Medical Practices
- Respiratory Medicine
- Diagnostic Imaging
Background:
- Preoperative guidelines often limit thoracic imaging for low-risk, asymptomatic patients.
- This approach aims to reduce unnecessary medical tests.
Purpose of the Study:
- To evaluate the potential risks of limiting preoperative thoracic imaging in seemingly healthy individuals.
- To highlight the importance of recognizing subtle symptoms in preoperative assessments.
Main Methods:
- Case review of two patients admitted to a respiratory department.
- Analysis of preoperative assessments and patient histories.
Main Results:
- Two patients with serious respiratory conditions (cavitary tuberculosis, small cell carcinoma) were diagnosed after undergoing procedures without preoperative chest radiography.
- Retrospective analysis revealed present but overlooked symptoms (cough, shortness of breath).
Conclusions:
- Overlooking common symptoms in preoperative evaluations can have severe consequences.
- Current practices of limiting preoperative thoracic imaging may require re-evaluation to prevent delayed diagnoses.
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