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Updated: May 31, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Side effects of evidence-based medicine
Antoine Fremault1, Daniel Rodenstein
1Clinique Saint-Joseph, Pneumology, Rue de la Duchere 6, Gilly, 6060, Belgium.
Abstract:
In the framework of an objective assessment of medical practices, it has become the rule to limit preoperative examinations, including thoracic imaging, in asymptomatic patients with a low surgical risk (that is, in "good health"). The insistence on the avoidance of "unnecessary" technical examinations in patients in seemingly good health may disregard common symptoms and lead to untoward consequences for the patients as we recently experienced in our respiratory department: two patients were admitted, one for a cavitary tuberculosis and the other one for a small cell carcinoma. These patients had uneventfully undergone in the recent weeks ear, nose and throat procedures and gynaecologic surgical procedures, respectively, without preoperative chest radiography as they were considered "asymptomatic" at the time of surgery. Retrospectively, ordinary symptoms (cough in the patient with cavitary tuberculosis and shortness of breath in the patient with lung carcinoma) were present but did not "ring a bell" during the preoperative assessment.
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