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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: May 31, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Evidence for the osteosarcoma stem cell.

C Parker Gibbs1, Padraic P Levings, Steven C Ghivizzani

  • 1University of Florida College of Medicine, Gainesville, FL.

Current Orthopaedic Practice
|July 15, 2011
PubMed
Summary
This summary is machine-generated.

Osteosarcoma, a bone cancer in young people, has limited survival rates. Understanding cancer stem cells and tumor cell heterogeneity is crucial for developing new, effective treatments beyond current therapies.

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Last Updated: May 31, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

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08:52

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Published on: June 13, 2018

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Published on: September 13, 2019

Area of Science:

  • Oncology
  • Cancer Biology
  • Genetics

Background:

  • Osteosarcoma is a malignant bone tumor affecting children and young adults.
  • Current treatments (chemotherapy and surgery) yield a 60% survival rate.
  • Traditional chemotherapy assumes cancer cells are identical, ignoring tumor heterogeneity.

Purpose of the Study:

  • To review evidence for cancer stem cells in osteosarcoma.
  • To explore the role of tumor cell heterogeneity in osteosarcoma.
  • To discuss the therapeutic implications of cancer stem cells for osteosarcoma treatment.

Main Methods:

  • Literature review of existing studies on osteosarcoma.
  • Analysis of evidence supporting cancer stem cell existence.
  • Examination of functional heterogeneity in osteosarcoma tumors.

Main Results:

  • Evidence suggests the existence of cancer stem cells in osteosarcoma.
  • Functional heterogeneity among osteosarcoma cells is increasingly recognized.
  • Cancer stem cells may be the origin of this heterogeneity.

Conclusions:

  • Understanding osteosarcoma heterogeneity is key to developing novel therapies.
  • Cancer stem cells represent a potential therapeutic target.
  • Targeting cancer stem cells could improve osteosarcoma treatment outcomes.