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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
(Pro)renin Receptor in Kidney Development and Disease.
1Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
International Journal of Nephrology
|July 15, 2011
Summary
The renin-angiotensin system (RAS) is crucial for kidney development, with its components expressed in the developing kidney. Aberrant RAS signaling, including the novel (pro)renin receptor (PRR), is linked to congenital kidney anomalies.
Area of Science:
- Nephrology
- Developmental Biology
- Endocrinology
Background:
- The renin-angiotensin system (RAS) regulates blood pressure and fluid balance.
- RAS components are present in the developing kidney (metanephros).
- Mutations in RAS genes cause congenital anomalies of the kidney and urinary tract (CAKUT).
Purpose of the Study:
- To describe the role of the RAS in kidney development.
- To highlight the function of the (pro)renin receptor (PRR) in kidney morphogenesis.
- To explore PRR signaling in cardiovascular and renal disease.
Main Methods:
- Review of existing literature on RAS and kidney development.
- Analysis of genetic studies linking RAS components to CAKUT.
- Examination of emerging evidence on PRR function.
Main Results:
- RAS is essential for normal kidney development.
- Defects in RAS components lead to various CAKUT.
- The (pro)renin receptor (PRR) is vital for kidney development.
- Aberrant PRR signaling is associated with renal and cardiovascular diseases.
Conclusions:
- The RAS plays a fundamental role in kidney development.
- PRR is a key regulator of kidney morphogenesis.
- Understanding PRR mechanisms may offer therapeutic targets for kidney diseases.
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