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Published on: July 3, 2014

Outcomes from intracerebral hemorrhage among patients pre-treated with statins

Flávio Ramalho Romero1, Eduardo de Freitas Bertolini, Vanessa Nogueira Veloso

  • 1Neurosurgery Service, Hospital Ipiranga, SUS, São Paulo SP, Brazil. frromero@ig.com.br

Arquivos De Neuro-Psiquiatria
|July 15, 2011
PubMed

Insights

Pre-ICH statin use did not impact functional independence or mortality in intracerebral hemorrhage (ICH) survivors. This study found no association between statin use before ICH and patient outcomes 90 days post-treatment.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Statins (HMG-CoA reductase inhibitors) are linked to better outcomes in ischemic stroke but may increase intracerebral hemorrhage (ICH) risk.
  • The effect of pre-ICH statin use on functional outcomes remains unclear.

Purpose of the Study:

  • To investigate the association between pre-ICH statin use and functional independence at 90 days.
  • To determine if statin use influences mortality rates in ICH patients.

Main Methods:

  • Prospective cohort study of 83 ICH patients with 90-day outcome data.
  • Statin usage confirmed via patient interviews and medical records.
  • Functional independence defined by Glasgow Outcome Scale (grades 4 or 5).

Main Results:

  • 24% (20/83) of patients used statins before ICH onset.
  • No significant difference in functional independence rates between statin users (28%) and non-users (29%).
  • Mortality rates were similar for both groups (46% vs. 45%).

Conclusions:

  • Pre-ICH statin use is not associated with altered functional outcomes.
  • Statin use before intracerebral hemorrhage does not appear to affect mortality.
Abstract

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