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Updated: May 31, 2026
P50 Sensory Gating in Infants
Published on: December 26, 2013
Pattern of P50 suppression deficit in patients with epilepsy and individuals with schizophrenia
Jefferson Becker1, Irenio Gomes da Silva Filho, Hélio Fernandes da Silva Filho
1Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre RS, Brazil. jeffersonbecker@hotmail.com
Objective:
To identify P50 suppression in patients with epilepsy, to investigate the effect of seizure control on P50 suppression, and to compare epilepsy patients with individuals with schizophrenia and healthy volunteers.
Method:
P50 evoked potential parameters and P50 suppression were studied crossectionally in patients with uncontrolled or controlled epilepsy, in individuals with schizophrenia and in healthy volunteers.
Results:
Individuals with schizophrenia had significantly smaller conditioning stimulus (S1) amplitude, and patients with epilepsy had larger test stimulus (S2) amplitude. Mean S2/S1 ratio was 0.71 ± 0.33 for patients with uncontrolled epilepsy; 0.68 ± 0.36 for patients with controlled epilepsy; 0.96 ± 0.47 for individuals with schizophrenia, and 0.42 ± 0.24 for healthy volunteers.
Conclusion:
The sensory filter of patients with epilepsy is altered, and this alteration is not associated with seizure control. Also, it works differently from the sensory filter of individuals with schizophrenia.
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